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Corso Integrato di Fisiologia Umana

PHYSIOLOGIC ADAPTATIONS TO THE STRESS

OF TREADMILL EXERCISE IN HEALTHY YOUNG

SUBJECTS

Cibelli et al., 2008

© G. Cibelli, 2008 58° Congresso SIF - 2007 14

Background

• The autonomic nervous system plays a substantial role in the

physiological adaptation of cardiovascular functions to change during

physical exercise

• In normal subjects exercise is associated with an augmentation of

sympathetic tone, whereas vagal tone is high during resting

conditions

• The concept of sympathovagal balance has arisen to characterize the

autonomic state resulting from these sympathetic and vagal

influences

• Heart rate variability (HRV) analysis has emerged as a prevalent

technique to assess autonomic influences on the heart (HRV) analysis

has emerged as a prevalent technique to assess autonomic influences

on the heart

• A number of stress markers, such as corrtisol and catecholamines,

have been found to reliably indicate reactivity of physiological stress

systems, e.g. the hypothalamic-pituitary-adrenal (HPA) axis and the

sympathetic nervous system (SNS) to exercise. Salivary a-amylase

has been suggested to reflect catecholaminergic reactivity to exercise

challange

© G. Cibelli, 2008 58° Congresso SIF - 2007 15

Aim of the study

• To test the effects of treadmill exercise on

salivary a-amylase and cortisol levels, as well

as on cardiovascular parameters, e. g. heart

rate (HR), blood pressure (BP) and HRV, in

healthy young subjects

• To find out possible correlations between

indices of sympathovagal balance and salivary

biomarkers

© G. Cibelli, 2008 58° Congresso SIF - 2007 16

Subjects and protocol

• Twentyfour healthy volunteers participated to this study

• After 6 minutes rest assessment, in upright position, each subject sat

on a treadmill ergometer (E-motion MTC Climb, Runner, Italy) and

performed an exercise test achieving 92±3% (submaximal level) of

the theoretical maximal heart reserve (computed as 220 – subject’s

age in years), using the Bruce protocol. After completion of the

exercise, subjects recovered for 6 additional minutes, still in upright

position

• A 12-lead ECG and a non invasive arterial blood pressure sampling

were recordered by a computer system (Corina, GE Medical System,

Italy) and a conventional sphygmomanometer, respectively

• Salivary samples collection was carried out at the beginning of the

rest, at the completion of the treadmill test and at the end of the

recovery. Samples were assayed for free cortisol and a-amilase by

commercially available kits (Salimetrics, PA).

© G. Cibelli, 2008 Anno Accademico 2007-2008 17

The treadmill exercise

© G. Cibelli, 2008 58° Congresso SIF - 2007 18

Heart rate variability (HRV)

• HR was used for heart rate variability (HRV) measures as

derived by the V4 lead and processed by the Biopac MP100A-

CE polygrapher. (Biopac System Inc., CA)

• HRV was computed in time and frequency domains. Power

spectral analysis on very-low frequences (VLF, 0 to 0.04 Hz),

low frequences (LF, 0.04 to 0.15 Hz) and high frequences (HF,

0.15 to 0.4 Hz) bands was expressed in ms2

• The LF/HF ratio was calculated from these values and

normalized LF (nLF) and HF (nHF) powers were calculated by

dividing the individual values by the total power, using the

Acqknowledge version 3.9.2-100 M.

© G. Cibelli, 2008 58° Congresso SIF - 2007 19

Descriptive statistics for the

anthropometric characteristics

© G. Cibelli, 2008 58° Congresso SIF - 2007 20

The physiological measures at

peak treadmill exercise

© G. Cibelli, 2008 58° Congresso SIF - 2007 21

Spectral analysis of HRV

© G. Cibelli, 2008 58° Congresso SIF - 2007 22

The effects of treadmill exercise

on cardiovascular variables

© G. Cibelli, 2008 58° Congresso SIF - 2007 23

The effects of treadmill exercise

on HRV indices

© G. Cibelli, 2008 58° Congresso SIF - 2007 24

The effects of treadmill exercise on

HPA and SNS reactivity biomarkers

© G. Cibelli, 2008 58° Congresso SIF - 2007 25

Correlations among cardiovascular

variables, HRV indices, HPA and SNS

biomarkers

© G. Cibelli, 2008 58° Congresso SIF - 2007 26


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AUTORE

kalamaj

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DESCRIZIONE APPUNTO

Appunti di Fisiologia umana I con attenzione ai seguenti argomenti: regolazione dell'apparato cardiovascolare, sistemi regolatori: sistema nervoso centrale, tono simpatico vasomotorio, controllo nervoso della pressione arteriosa, effetti cardiovascolari dell'eccitazione o inibizione del bulbo rostroventrolaterale, eccitazione e inibizione gabaergica, omeostasi cardiovascolare.


DETTAGLI
Corso di laurea: Corso di laurea magistrale in medicina e chirurgia (a ciclo unico - 6 anni)
SSD:
Università: Foggia - Unifg
A.A.: 2012-2013

I contenuti di questa pagina costituiscono rielaborazioni personali del Publisher kalamaj di informazioni apprese con la frequenza delle lezioni di Fisiologia Umana I e studio autonomo di eventuali libri di riferimento in preparazione dell'esame finale o della tesi. Non devono intendersi come materiale ufficiale dell'università Foggia - Unifg o del prof Cibelli Giuseppe.

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